Salicylic acid amplifies Carbachol-induced bronchoconstriction in human precision-cut lung slices
نویسندگان
چکیده
منابع مشابه
Biaxial distension of precision-cut lung slices.
The mechanical forces acting on lung parenchyma during (mechanical) ventilation and its (patho)physiological consequences are currently under intense scrutiny. Several in vivo and cell culture models have been developed to study the pulmonary responses to mechanical stretch. While providing extremely useful information, these models do also suffer from limitations in being either too complex fo...
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Cytokines play an essential role in the regulation of inflammatory responses. The effects of cytokines on lung functions are less well known and their study in vivo is complicated by the attraction of leukocytes to the inflamed sites. Recently the model of precision-cut lung slices was developed, where viable lung slices with an intact microanatomy are taken into culture and where bronchoconstr...
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O. Danov1, S. M. Jiménez Delgado1, H. Drake1, S. Seehase2, A. M. Hohlbaum3, C. Bersch4, D. Jonigk5, G. Warnecke6, A. Braun1 and K. Sewald1 1Airway Immunology, Fraunhofer Institute for toxicology and experimental Medicine, Biomedical Research in endstage and Obstructive lung Disease Hannover (BReAtH), Member of the German Centre for lung Research (DZl), Hannover, Germany; 2Clinical & experimenta...
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Objective(s): Precision-cut tissue slices are considered an organotypic 3D model widely used in biomedical research. The comet assay is an important screening test for early genotoxicity risk assessment that is mainly applied on in vitro models. The aim of the present study was to provide a 3D organ system for determination of genotoxicity using a modified method of the comet assay since the s...
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BACKGROUND Glucocorticoids have been proven to be effective in the therapy of recurrent airway obstruction (RAO) in horses via systemic as well as local (inhalative) administration. Elective analysis of the effects of this drug on bronchoconstriction in viable lung tissue offers an insight into the mechanism of action of the inflammatory cascade occurring during RAO which is still unclear. The ...
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ژورنال
عنوان ژورنال: Respiratory Research
سال: 2019
ISSN: 1465-993X
DOI: 10.1186/s12931-019-1034-x